March 5, 2021
Steven Grover, PhD awarded a CSL Behring Prof Heimburger Award Congratulations to Steven Grover, PhD, a postdoctoral fellow in the laboratory of Nigel Mackman, PhD, who has been awarded a 2021 Prof Heimburger Award from CSL Behring. This award will provide research support for his project “Evaluating the anticoagulant activity of C1 esterase inhibitor in …
February 21, 2021
Congratulations to Steven Grover, PhD, a postdoctoral fellow in the laboratory of Nigel Mackman, PhD, who has been awarded a Journal of Thrombosis and Haemostasis Editors Award for his recent publication “Model‐dependent contributions of FXII and FXI to venous thrombosis in mice”. The award consists of a certificate, to be presented at the JTH Editors Luncheon held at the ISTH Congress, …
January 21, 2021
Dr. Alisa Wolberg, Scientific Co-Chair of the American Society of Hematology 2020 meeting, was interviewed about abstracts selected for the Best of ASH for the podcast “Blood & Cancer”. The episode is available at this link, and can be accessed via any platform you use to listen to podcasts. Alisa Wolberg, PhD
January 19, 2021
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells. Authors: Giang N. Nguyen, John K. Everett, Samita Kafle, Aoife M. Roche, Hayley E. Raymond, Jacob Leiby, Christian Wood, Charles-Antoine Assenmacher, Elizabeth P. Merricks, C. Tyler Long, Haig H. Kazazian, Timothy C. Nichols, Frederic D. Bushman …
January 19, 2021
Congratulations to Erica Sparkenbaugh, Assistant Professor in the UNC Department of Medicine Hematology, and member of the Blood Research Center. She has been awarded a five year, $2 million R01 grant from NIH-NHLBI beginning January 2021. The goal of this project is to evaluate whether activation of beneficial PAR1 signaling can attenuate the chronic pro-coagulant …
December 16, 2020
Improving Immunizations in Patients with Non-Malignant Hematological Disorders Receiving Immunosuppressive Therapy article Based on research findings of Drs. Malpica and Moll Read article, ASH invited Dr. Moll to moderate and Dr. Malpic to present at an education session on “Preventing Infections when treating non-malignant hematology disorders” at the annual ASH meeting on Dec 7, 2020. …
December 15, 2020
COVID-19 is associated with derangements in biomarkers of coagulation and endothelial cell function and has been likened to abnormalities seen in sepsis. Emma Bouck and Alisa Wolberg, PhD collaborated with investigators at the University of Utah to show that both COVID-19 and sepsis are associated with activation of mechanisms that promote clot formation and clot …
December 15, 2020
Research in the Aleman Lab is centered on basic mechanisms regulating erythropoiesis in health and disease. Differentiation of hematopoietic stem cells down the erythroid track requires coordinated gene expression, including RNA regulation, and accumulation of iron for hemoglobin production. Our current work focuses on a family of bifunctional proteins (poly C binding proteins) which both regulate RNA processing and chaperone iron within cells. Using biochemical, cellular, and in vivo models we explore the cross talk between iron trafficking and RNA regulation mediated by poly C binding proteins and how these activities are modulated by disease.
December 14, 2020
The Bahnson Research Group studies Redox Biology in Cardiovascular Disease and the development of targeted nanocarriers to deliver therapeutics.
December 9, 2020
Congratulations to Silvio Antoniak, Phd with NCSU collaborator James C. Bonner! Grant application titled “Role of PAR-2 in nanoparticle modulation of allergic lung disease” The NC TraCS proposal investigates the contribution of lung macrophage PAR2 on allergic airway disease caused by multi-walled carbon nanotubes (MWCNTs). We propose that common allergens like house dust mite allergens …
December 2, 2020
R35 grant awarded to Nigel Mackman, PhD (PI) from NHLBI/NIH The award is a 7 year grant with $600,000/year directs costs and a total amount of $6.46million. The title is “Tissue factor-dependent coagulation in thrombosis and immune responses”. The proposal will study the mechanisms of thrombosis in cancer and viral infections, including influenza A infection …
November 5, 2020
Congratulations to Patrick Ellsworth, MD, awarded the ASH Research Restart Award. This award is for $50,000 for the twelve-month term beginning November 2020. One of the Society’s newest programs, the ASH Research Restart Award program is designed to reduce the impact that the global COVID-19 pandemic response has had on the progression of research and …