June 10, 2024
A manuscript entitled “Disease severity drives thrombosis risk in women with sickle cell disease in a single-center retrospective study” was recently accepted in Research and Practice in Thrombosis and Haemostasias. The research was initiated by Jennifer Light, MD, during her fellowship in the UNC Pediatrics Division of Hematology and Oncology. She performed her basic research …
June 7, 2024
A new MPI NIH R01 was awarded to Alisa Wolberg, PhD and Karin Leiderman, PhD of University of North Carolina at Chapel Hill School of Medicine, entitled: “Interdisciplinary Approach to Elucidate Modifiers of Bleeding Phenotype in Factor XI Deficiency.” The Research Project Grant (R01) is the original and historically oldest grant mechanism used by NIH. …
June 7, 2024
Jamie Madrigal, Mac Monroe, Suzanne Sindi, Karin Leiderman, from The University of North Carolina at Chapel Hill School of Medicine, had a new paper published in Mathematical Biosciences. “Modeling the Distribution of Enzymes on Lipid Vesicles: A Novel Framework for Surface-Mediated Reactions in Coagulation”. Abstract Blood coagulation is a network of biochemical reactions wherein dozens …
June 5, 2024
Abigail Ballard-Kordeliski, Robert H. Lee, Ellen Clelia O’Shaughnessy, Paul Y. Kim, Summer R Jones, Rafal Pawlinski, Matthew J. Flick, David S. Paul, Nigel Mackman, David Adalsteinsson, Wolfgang Bergmeier all of University of North Carolina at Chapel Hill had their research published in the journal Blood. Title: 4D intravital imaging identifies platelets as the predominant …
June 5, 2024
Sam Pflum, PhD Clinical Assistant Professor at the UNC School of Medicine is fundraising for families with Sickle Cell Disease. On community fundraising Sam writes: “While you probably know me to have many passions and roles, today I come to you from the intersection of being a pediatric psychologist who moonlights as a novice triathlete. …
May 28, 2024
May 2024 Newsletter
May 23, 2024
Steven Grover, PhD received the 2024 Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis at the American Heart Association Vascular Discovery meeting. At the meeting Dr. Grover presented his groups recent research on the role of plasma kallikrein as a key driver of coagulation under conditions of C1-inhibitor deficiency. The Kenneth M. Brinkhous Prize recognizes outstanding …
May 22, 2024
Congratulations to Linda Sundler Björkman MD, PhD, currently a postdoctoral fellow in the lab of Steven Grover, PhD, whose article “Increased risk of venous thromboembolism in young and middle-aged individuals with hereditary angioedema: a family study” has been accepted for publication in the journal Blood! This work, conducted in collaboration with colleagues from Lund University, …
May 21, 2024
Dr. Stephan Moll coauthored an article published on May 15, 2024 in the New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/NEJMc240259 ) expanding on an earlier observation (Warkentin TE et al. https://www.nejm.org/doi/full/10.1056/NEJMc2307721 ) that adenoviral infection can be associated with a clinical picture of severe thrombosis and thrombocytopenia, triggered by antibody formation against platelet factor 4 (PF4), …
May 7, 2024
The International Society of Thrombosis and Haemostasis (ISTH) announces Alisa Wolberg, PhD as one of the recipients of its inaugural Outstanding Mentor Award for 2024. The Outstanding Mentor Awards are a new award from the ISTH in 2024, recognizing individuals who have demonstrated an ongoing commitment to cultivate and mentor early career professionals in the …
April 22, 2024
Drs. Ramadas, Trebak, Pawlinski and Sparkenbaugh are co-authors of “Biased agonism of protease-activated receptor-1 regulates thrombo-inflammation in murine sickle cell disease” and their manuscript was accepted in Blood Advances. In this study, they showed that APC inhibition exacerbates thrombin generation, inflammation and end-organ damage in a mouse model of sickle cell disease (SCD), and that APC-PAR1 …
April 3, 2024
Drs. Hisada, Key, and Mackman are co-authors of “Biomarkers of bleeding and venous thromboembolism in patients with acute leukemia” and their manuscript was accepted by The Journal of Thrombosis and Haemostasis. In this manuscript, they showed that increased extracellular vesicle tissue factor activity is associated with bleeding whereas increased plasminogen activator inhibitor-1 levels are associated …