Department of Genetics Publications for June 9th – 22nd, 2024

Department of Genetics faculty, postdocs, students and collaborators published 12 papers during June 9th – 22nd, 2024.

 

Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes. 

Ilangovan H, Kothiyal P, Hoadley KA, Elgart R, Eley G, Eslami P.

NPJ Microgravity. 2024 Jun 11;10(1):61. doi: 10.1038/s41526-024-00379-3.

PMID: 38862523 Free PMC article.

 

A corpus of GA4GH Phenopackets: case-level phenotyping for genomic diagnostics and discovery. 

Danis D, Bamshad MJ, Bridges Y, Cacheiro P, Carmody LC, Chong JX, Coleman B, Dalgleish R, Freeman PJ, Graefe ASL, Groza T, Jacobsen JOB, Klocperk A, Kusters M, Ladewig MS, Marcello AJ, Mattina T, Mungall CJ, Munoz-Torres MC, Reese JT, Rehburg F, Reis BCS, Schuetz C, Smedley D, Strauss T, Sundaramurthi JC, Thun S, Wissink K, Wagstaff JF, Zocche D, Haendel MA, Robinson PN.

medRxiv [Preprint]. 2024 May 29:2024.05.29.24308104. doi: 10.1101/2024.05.29.24308104.

PMID: 38854034 Free PMC article. Preprint.

 

Regulatory T cells effectively downregulate the autoimmune anti-MPO response and ameliorate anti-MPO induced glomerulonephritis in mice. 

Hu P, Xiao H, Elmore S, Agosto-Burgos C, Hu Y, Hogan SL, Ciavatta DJ, Falk RJ, Jennette JC, Free ME.

J Autoimmun. 2024 Jun 7;147:103266. doi: 10.1016/j.jaut.2024.103266. Online ahead of print.

PMID: 38851088

 

Biases in ARG-based inference of historical population size in populations experiencing selection. 

Marsh JI, Johri P.

Mol Biol Evol. 2024 Jun 14:msae118. doi: 10.1093/molbev/msae118. Online ahead of print.

PMID: 38874402

 

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation. 

Crain AT, Butler MB, Hill CA, Huynh M, McGinty RK, Duronio RJ.

Genes Dev. 2024 Jun 12. doi: 10.1101/gad.351698.124. Online ahead of print.

PMID: 38866557

 

A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice

Reisemberg EL, Smeekens JM, Cruz Cisneros MC, Hampton BK, Hock P, Linnertz C, Miller DR, Orgel K, Shaw G, Pardo Manuel de Villena F, Burks AW, Valdar V, Kulis MD, Ferris MT.

J Allergy Clin Immunol. 2024 Apr 24:S0091-6749(24)00411-1. doi: 10.1016/j.jaci.2024.03.027. Online ahead of print. PMID: 38670234.

 

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease. 

Bergstedt J, Pasman JA, Ma Z, Harder A, Yao S, Parker N, Treur JL, Smit DJA, Frei O, Shadrin AA, Meijsen JJ, Shen Q, Hägg S, Tornvall P, Buil A, Werge T, Hjerling-Leffler J, Als TD, Børglum AD, Lewis CM, McIntosh AM, Valdimarsdóttir UA, Andreassen OA, Sullivan PF, Lu Y, Fang F.

Nat Cardiovasc Res. 2024;3(6):754-769. doi: 10.1038/s44161-024-00488-y. Epub 2024 Jun 17.

PMID: 38898929 Free PMC article.

 

Multi-organ imaging-derived polygenic indexes for brain and body health. 

Yang X, Sullivan PF, Li B, Fan Z, Ding D, Shu J, Guo Y, Paschou P, Bao J, Shen L, Ritchie MD, Nave G, Platt ML, Li T, Zhu H, Zhao B.

medRxiv [Preprint]. 2024 Jun 3:2023.04.18.23288769. doi: 10.1101/2023.04.18.23288769.

PMID: 38883759 Free PMC article. Preprint.

 

Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma. 

Yu L, Deng Y, Wang X, Santos C, Davis IJ, Earp HS, Liu P.

Nat Commun. 2024 Jun 21;15(1):5292. doi: 10.1038/s41467-024-49667-2.

PMID: 38906855

 

Identification and genetic analysis of a pervasive ‘needle-eye’ sperm phenotype in Drosophila sterile hybrid males. 

Kanippayoor RL, Soeder C, Hsiang T, Jones CD, Moehring AJ.

Proc Biol Sci. 2024 Jun;291(2025):20240483. doi: 10.1098/rspb.2024.0483. Epub 2024 Jun 19.

PMID: 38889778

 

Incidence of clinically relevant postoperative pancreatic fistula in patients undergoing open and minimally invasive pancreatoduodenectomy: a population-based study. 

Chang JH, Kakati RT, Wehrle C, Naples R, Joyce D, Augustin T, Simon R, Walsh RM, Dahdaleh FS, Spanheimer P, Salti I, Parente A, Naffouje SA.

J Minim Invasive Surg. 2024 Jun 15;27(2):95-108. doi: 10.7602/jmis.2024.27.2.95.

PMID: 38887001 Free PMC article.

 

Trends in the use of immunotherapy to treat soft tissue sarcoma. 

Iwai Y, Baldwin XL, Feeney T, Agala CB, Yanagihara TK, Stein JN, Kim HJ, Spanheimer PM.

Am J Surg. 2024 Jun 5:115794. doi: 10.1016/j.amjsurg.2024.115794. Online ahead of print.

PMID: 38879356