Bev Koller, PhD, Associate Professor of Genetics, was awarded a new R21 from the National Institute of Allergy and Infectious Diseases (NIAID) titled “Mouse models for study of the NLRP1 and CARD8 inflammasomes”.
The goal of this project is to utilize syntenic replacement to generate novel mouse lines expressing human NLRP1 and CARD8. Generation of these mouse lines will enable the research community to investigate the contribution of these individual inflammasomes to the immune response, specifically host defense and pathogeneses of inflammatory diseases.