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The UNC School of Medicine opened the Wilmington Campus in March 2016. Though the branch campus was new at the time, Wilmington has been successfully teaching UNC medical students for decades. UNC School of Medicine students may choose to spend all of their Application Phase and most or all of their Individualization Phase at the Wilmington Campus. Three students began the inaugural class, followed by four students the subsequent year. Since then, the campus has grown steadily, now the home of 18-24 Application Phase students with typically 60-75% remaining for Individualization Phase.

In addition to completing core clerkships, students have various longitudinal opportunities as they become available, including but not limited to obtaining a scholarship to complete a Leadership Certificate Program and participation in Pregnancy Centering Care Teams. Students are also given the flexibility and support to complete a quality improvement project in an array of specialties, obstetrics and gynecology, surgery and medicine. The Wilmington Program follows the same curricular structure as the Central Program, which is comprised of four courses that integrate medical specialties.