Category: Oncology
Experimental Drug That Boosts Immunotherapy, Shows Promise in Bladder Cancer Study
A new study in mice found that adding the experimental drug entinostat to an immunotherapy-like treatment substantially boosted cancer remission. This approach shows such promise that it’s already being tested in an ongoing clinical trial in people with advanced bladder cancer. This finding, led by William Kim, MD, professor of medicine in the division of oncology and member of t … Read more
ONCLive Features Carey Discussing Updated Results of PALOMA-3 Trial
Lisa A. Carey, MD, FASCO, the Richardson and Marilyn Jacobs Preyer Distinguished Professor for Breast Cancer Research in the Department of Medicine’s Division of Oncology recently discussed the updated results of the phase 3 PALOMA-3 trial (NCT01942135) in hormone receptor (HR)–positive, HER2-positive breast cancer. Hear Carey explain the results on ONCLive.
Zeidner Discusses Pevonedistat Which Shows Promising Partner Potential for HMAs in Higher-Risk MDS
Joshua F. Zeidner, MD, discussed the role hypomethylating agents (HMAs) have played in the treatment of higher-risk myelodysplastic syndrome (MDS) in a recent OncLive report. He shared data that shows promising emerging agents like pevonedistat that can be combined with HMAs to improve outcomes for certain patient subsets. “We really have not had any new agents for patients with … Read more
Advanced Bladder Cancers Respond to Immunotherapy Regardless of Gene Mutation Status
A new study demonstrates patients with advanced bladder cancers whose tumors have a mutated FGFR3 gene respond to immunotherapy treatment in a manner that is similar to patients without that mutation, a discovery that runs counter to previous assumptions. Led by scientists in the Department of Medicine and members of the Lineberger Comprehensive Cancer Center, the study has impor … Read more
Department of Medicine Grants & Funding: July 1 – July 31, 2021
Division of Infectious Diseases Ed Browne, PhD, received a $4-million NIH grant to study the effects of cannabis use on the HIV reservoir. The Doris Duke Charitable Foundation has awarded Ross Boyce, MD, MSc, a 2021 Clinical Scientist Development Award for his research proposal entitled, “Getting malaria off the back of women and children in western Uganda,” which aims at reducin … Read more
ASCO Grant Supports Charlot’s Study of An App to Encourage Black Women to Participate in Breast Cancer Research
Marjory Charlot, MD, MPH, MSc, assistant professor of medicine in the division of oncology and member of the UNC Lineberger Comprehensive Cancer Center was named the 2021 recipient of the Conquer Cancer Advanced Clinical Research Award for Diversity and Inclusion. The honor includes a three-year, $450,000 grant from Conquer Cancer, the American Society of Clinical Oncology’s (ASC … Read more
Advances Propel Lung Cancer Paradigms Forward to Improved Outcomes and Quality of Life
Among a plethora of novel immunotherapeutic and targeted agents, the treatment landscapes for small cell lung cancer and non–small cell lung cancer have witnessed a rapid expansion that has led to improved survival and quality of life for patients, including a wider range of patients who harbor molecular abnormalities. In an interview with OncLive® during an Institutional Perspec … Read more
Department of Medicine Grants & Funding: June 1 – June 30, 2021
Division of Endocrinology and Metabolism Klara Klein, MD, PhD, received a physician-scientist award to cultivate her career as a translational clinician scientist. Division of Gastroenterology and Hepatology Resident Corey Ketchem, MD, received the Bondurant-Ehringhaus Award to support research with Evan Dellon, MD, MPH, on eosinophilic esophagitis (EoE) and other esophageal dise … Read more
We Usually Don’t Vote on Intubation
Christopher Jensen, MD, a hematology-oncology fellow, with Katherine “Alex” Despotes, MD, and Benjamin DeMarco, MD, fellows in the division of pulmonary and critical care medicine, recently published “We Usually Don’t Vote on Intubation” in the Chest Journal. Their essay tells the story of a patient who requested the opportunity to cast her vote in the recent election before intu … Read more
Two Medicine Scholars Named to Physician-Scientist Training Program
Klara Klein, MD, PhD, a fellow in the division of endocrinology and metabolism, and Shetal Patel, MD, PhD, assistant professor of medicine in the division of oncology, have received physician-scientist awards to cultivate their careers as translational clinician scientists. As part of the Forward Together Strategic Plan, the UNC School of Medicine Physician Scientist Training Pro … Read more
Ray Receives ASCO Conquer Cancer Grant Award
Emily Ray, MD, MPH, has received a three-year Conquer Cancer Career Development Award from the American Society of Clinical Oncology for a study that will evaluate and validate the use of a prognostic calculator for 30-day mortality in patients with metastatic breast cancer. The project aims to improve outcomes for patients by providing evidence-based estimates of prognosis, and … Read more
Triangle Colon Cancer Survivors Encourage Earlier Screening As Panel Drops Recommended Age to 45
ABC-11 news reports how colorectal cancer is the second leading cause of U.S. cancer deaths, and that health officials are concerned about increases in younger people. Hanna Sanoff, MD, associate professor of medicine in the division of oncology, and clinical medical director at the N.C. Cancer Hospital and UNC Lineberger Comprehensive Cancer Center, said she has seen an increase … Read more