Obesity is a known risk factor for various cancers, and its rise over the past few decades has contributed to a rise in hormone receptor positive breast cancer rates that is greater in Black women than White women. At the same time, as overall breast cancer mortality rates have declined, the decline has been less pronounced in Black women, producing a 40% mortality gap.
In an analysis of women with early breast cancer, led by Kirsten Nyrop, PhD, Black women had higher rates of obesity and other health conditions that can affect prognosis and survival, compared with White women. The findings were published in Cancer, a peer-reviewed journal of the American Cancer Society (ACS).
The study team analyzed health data for 548 patients treated at their hospital for early breast cancer. They found 62% of Black patients and 32% of White patients were obese, and higher percentages of Black women had obesity-related comorbidities, such as hypertension, diabetes, and high cholesterol, compared to White women. Yet, despite significant differences in the prevalence of obesity and comorbidities, there were no differences between Black and White patients in treatment decisions with regard to type of surgery, chemotherapy, radiation, or endocrine therapy.
“Findings from this study need to be considered within the larger context of the cancer-obesity link and the disparate impact of the obesity epidemic on communities of color in the United States,” said Nyrop, assistant professor in the division of oncology and member of UNC Lineberger Comprehensive Cancer Center.
“Early breast cancer is highly treatable, and survival rates have improved steadily due to treatment advances and early detection through mammograms; however, the high rates of obesity, overall comorbidities, and obesity-related comorbidities observed among women with early breast cancer—especially among Black women—can contribute to disparities in overall survival of these patients.”
Nyrop also recognized that the rates of many cancers impacted by obesity are higher in Black women, as are the rates of numerous obesity-related conditions such as diabetes and hypertension. “As the COVID-19 pandemic has glaringly underscored, there is an urgent need to address the systemic and socioeconomic aspects of obesity that disproportionately affect minority communities in the U.S. if we are to reverse health disparities.”
Other authors include Emily M Damone, BS; Allison M. Deal, MS; Lisa A. Carey, MD; Michael Lorentsen, MD; Schlomit S. Shachar, MD; Grant W. Williams, MD; Addison (Tucker) Brenizer, BS; Amy Wheless, MA; and Hyman B. Muss, MD.