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Our lab is interested in epigenetic and transcriptional regulation of conventional and unconventional T cell development, differentiation and function.
Our research aims to decipher how aberrations in T cell biology can result in disease emergence such as inflammation, autoimmunity and cancer. We also aim to understand how we can reprogram the immune system to treat more efficiently disease and improve health outcomes. The last years we have been focusing our studies on the Ten Eleven Translocation (TET) family of proteins, which are involved in DNA demethylation and play critical tumor suppressive roles.
To address our questions we use mouse genetics, genomics and a vast array of immunological, biochemical and molecular biology assays.
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UNC AFFILIATIONS:
Genetics, Lineberger Cancer Center, Microbiology & Immunology |
CLINICAL/RESEARCH INTERESTS:
Biochemistry, Cancer Biology, Cell Biology, Developmental Biology, Epigenetics and Chromatin Biology, Genetics, Genomics, Immunology, Molecular Biology, Molecular Medicine, Systems Biology |