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The lab’s research is centered on G proteins, RGS proteins, and G protein-coupled receptors (GPCRs). The lab has long been conducting large-scale genomic and proteomic analysis, in yeast, to identify mutants with altered signaling and desensitization properties. These variant proteins are then characterized biochemically, using both yeast and mammalian components.
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UNC AFFILIATIONS:
Biochemistry & Biophysics, Bioinformatics & Computational Biology, Lineberger Cancer Center, Pharmacology |
CLINICAL/RESEARCH INTERESTS:
Biochemistry, Cell Signaling, Drug Discovery, Genomics, Molecular Biology, Pharmacology, Quantitative Biology, Systems Biology |