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Chromatin remodeling plays a critical role in regulating all processes that require access to DNA. There are four families of chromatin remodelers, defined by the ATPase subunit of the complex. Although each family is often treated as a singular entity, in reality, the composition of remodeling complexes can vary greatly based on the inclusion of different subunits. Changes to composition are found throughout development and disease, and are especially frequent in cancer. The details of how altered chromatin remodeler composition contributes to disease is complicated by the myriad combinations possible and remains poorly understood.
The goal of our lab is to understand how the composition of a chromatin remodeling complex is regulated, and how altered chromatin remodeling disrupts normal chromatin state and contributes to disease. Recently we have focused on how disruption of chromatin regulation affects normal liver biology and can lead to liver cancer. Our work integrates quantitative genomics, biochemistry, and molecular biology to develop a mechanistic understanding of how changes to the composition of a chromatin remodeling complex affects its function.
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UNC AFFILIATIONS:
Center for GI Biology and Disease (CGIBD), Genetics, Lineberger Cancer Center |
CLINICAL/RESEARCH INTERESTS:
Cancer Biology, Drug Discovery, Epigenetics and Chromatin Biology, Gastrointestinal Biology, Genetics, Genomics, Molecular Biology, Molecular Medicine, Regenerative Medicine |