Publications
2023
Open-label study of the efficacy, safety, and durability of peanut sublingual immunotherapy in peanut allergic children Jun 2023 [Kim, Keet, Virkud, Penumarti, Smeekens, Guo, Yue, Kulis, Burks]
The SunBEAm birth cohort: Protocol design Aug 2023 [Keet, Kim]
Environmental Exposure to Foods as a Risk Factor for Food Allergy Aug 2023 [Turner, Smeekens]
A single priming event prevents oral tolerance to peanut Sep 2023 [Smeekens, Kesselring, Turner, Kulis, Moran]
Desensitization and remission after peanut sublingual immunotherapy in 1-to-4-year-old peanut-allergic children: A randomized, placebo-controlled trial Oct 2023 [Kim, Keet, Virkud, Herlihy, Smeekens, Guo, Yue, Penumarti, Kulis, Burks]
Frequency and predictors of multisystem reactions to peanut in infant oral food challenges Oct 2023 [Keet]
2022
Home Introduction of Baked Egg after Oral Food Challenge Oct 2022 [Keet]
Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy Sept 2022 [Burks, Guo, Iweala, Kulis, Suber, Ye, Zhang]
Preventing allergies through the skin Sept 2022 [Keet, Winslow]
Allergen recognition by specific effector Th2 cells enables IL-2-dependent activation of regulatory T-cell responses in humans Sept 2022 [Burks]
Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis Sept 2022 [Virkud]
Peanut anaphylaxis in 2022: Decoupling epinephrine usage from emergency department evaluation Sept 2022 [Kim, Winslow]
Treatment for food allergy: Current status and unmet needs Aug 2022 [Kim]
Peanut-Specific IgG4 and IgA in Saliva Are Modulated by Peanut Oral Immunotherapy Aug 2022 [Burks, Kim, Kulis, Smeekens]
A “LEAP” forward in understanding immune mechanisms of oral tolerance to peanut Aug 2022 [Kulis, Moran]
Single-dose AAV vector gene immunotherapy to treat food allergy July 2022 [Kulis]
Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results July 2022 [Kim]
Targeting CD22 on memory B cells to induce tolerance to peanut allergens July 2022 [Burks, Kulis, Hardy, Smeekens]
Evaluation of a group visit model for access to infant and toddler oral food challenges Jun 2022 [Virkud]
Comparative efficacy of mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis Jun 2022 [Keet]
Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy Jun 2022 [Kim]
Safety of peanut (Arachis hypogaea) allergen powder-dnfp in children and teenagers with peanut allergy: Pooled summary of phase 3 and extension trials Jun 2022 [Burks]
Kinetics of basophil hyporesponsiveness during short-course peanut oral immunotherapy Jun 2022 [Burks, Guo, Hamilton, Herlihy, Keet, Kim, Kulis, Li, Smeekens, Ye, Yue]
Prospective associations between acid suppressive therapy and food allergy in early childhood May 2022 [Virkud]
Effective methods of clinical education Mar 2022 [Kim]
The year in food allergy Mar 2022 [Keet]
Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts Apr 2022 [Burks, Kim]
Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study Jan 2022 [Burks, Kim, Kulis]
Bringing the Next Generation of Food Allergy Diagnostics Into the Clinic Jan 2022 [Kulis]
2021
Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities Dec 2021 [Kulis, Smeekens]
Mapping Sequential IgE-Binding Epitopes on Major and Minor Egg Allergens Nov 2021 [Burks]
The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis Sept 2021 [Kulis, Moran, Smeekens]
Heterogeneity in Parent Preferences for Peanut Desensitization Therapy Sept 2021 [Kim]
Caregiver perceptions and attitudes associated with oral immunotherapy on social media Sept 2021 [Keet]
Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study May 2021 [Burks]
Shorter “time to peanut introduction” can prevent peanut allergy and avert false Ara h 2 screening results in infants May 2021 [Iglesia, Kim]
Increasing diversity in peanut oral immunotherapy research and accessibility May 2021 [Kim]
Epicutaneous immunotherapy for treatment of peanut allergy: Follow-up from the Consortium for Food Allergy Research Mar 2021 [Burks, Kim]
Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice Jan 2021 [Burks, Hinton, Kesselring, Kulis, Smeekens, Steinbach]
Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy Jan 2021 [Kulis, Moran, Smeekens]
Current Insights into Immunotherapy Approaches for Food Allergy Jan 2021 [Burks, Kim]
Five-year follow-up of early intervention peanut oral immunotherapy Jan 2021 [Barber, Burks, Herlihy, Hamilton, Kim]
Mechanisms of oral immunotherapy Jan 2021 [Barshow, Burks, Kim, Kulis]
Irradiated Tree Nut Flours for Use in Oral Immunotherapy Jan 2021 [Burks, Kesselring, Kim, Kulis, Penumarti]
2020
Model of Walnut Allergy in CC027/GeniUnc Mice Recapitulates Key Features of Human Disease Dec 2020 [Kesselring, Kulis, Smeekens]
Strategies for Mast Cell Inhibition in Food Allergy Dec 2020 [Iweala, Suber]
Early epitope-specific IgE antibodies are predictive of childhood peanut allergy Nov 2020 [Burks]
Irradiated Tree Nut Flours for Use in Oral Immunotherapy Nov 2020 [Burks, Kesselring, Kim, Kulis, Penumarti, Sheth]
Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research Oct 2020 [Burks, Kulis]
Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy Oct 2020 [Burks, Kim]
Dosing, safety, and quality of life after peanut immunotherapy trials: A long-term follow-up study Sept 2020 [Barber, Burks, Herlihy, Kim]
Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy Sept 2020 [Kulis, Smeekens]
IgE producers in the gut expand the gut’s role in food allergy Jul 2020 [Burks, Iweala]
Food allergy immunotherapy: Oral immunotherapy and epicutaneous immunotherapy Jun 2020 [Burks, Kim]
Legends of allergy and immunology: Hugh A. Sampson Jun 2020 [Burks]
A 5-year summary of real-life dietary egg consumption after completion of a 4-year egg powder oral immunotherapy (eOIT) protocol Apr 2020 [Burks, Kim]
Peanut applied to the skin of nonhuman primates induces antigen-specific IgG but not IgE Mar 2020 [Kulis, Smeekens]
Systematic quantification of the dynamics of newly synthesized proteins unveiling their degradation pathways in human cells Mar 2020 [Smeekens]
Immunotherapy approaches for peanut allergy Feb 2020 [Burks, Kim, Patel]
Evolution of Immune Responses in Food Immunotherapy Feb 2020 [Kulis, Smeekens]
2019
Biomarkers in Food Allergy Immunotherapy Dec 2019 [Hardy, Kulis, Smeekens]
A Novel Allergen-Specific Immune Signature-Directed Approach to Dietary Elimination in Eosinophilic Esophagitis Dec 2019 [Burks, Guo, Hamilton, Kulis]
Evolution of Immune Responses in Food Immunotherapy Nov 2019 [Kulis, Smeekens]
IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy Oct 2019 [Burks, Kulis]
Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization Sep 2019 [Burks, Guo, Kim, Kulis, Ye]
Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway Sep 2019 [Kulis, Smeekens]
Clinical factors associated with peanut allergy in a high-risk infant cohort Jul 2019 [Burks]
Plant cell-made protein antigens for induction of Oral tolerance Jun 2019 [Kulis]
Hypoallergenic Proteins for the Treatment of Food Allergy Feb 2019 [Kulis]
Dosing and Safety of Peanut Food Equivalents After Immunotherapy Trials Feb 2019 [Barber, Burks, Herlihy, Kim]
Back to Life, Back to Reality – What Happens after Peanut Immunotherapy? A Long-Term Follow up Study on Perceptions of Safety and Lifestyle Feb 2019 [Barber, Burks, Herlihy, Kim]
The Consortium for Food Allergy Research (CoFAR): The first generation Feb 2019 [Burks]
2018
Blocking antibodies induced by peanut oral and sublingual immunotherapy suppress basophil activation and are associated with sustained unresponsiveness Nov 2018 [Burks, Guo, Hardy, Kulis, Smeekens, Suber]
AR101 Oral Immunotherapy for Peanut Allergy Nov 2018 [Burks, Kim]
Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy Oct 2018 [Burks, Guo, Kulis, Smeekens, Ye]
Antigenic Liposomes for Generation of Disease-specific Antibodies Oct 2018 [Hardy, Kulis, Smeekens]
Adjuvanted Immunotherapy Approaches for Peanut Allergy Sep 2018 [Burks, Kulis]
High- and low-dose oral immunotherapy similarly suppress pro-allergic cytokines and basophil activation in young children Sep 2018 [Burks, Guo, Kim, Kulis, Ye, Yue]
Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research Aug 2018 [Burks]
Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy Jul 2018 [Burks]
A Mouse Model of Peanut Allergy Induced by Sensitization Through the Gastrointestinal Tract Jun 2018 [Kulis]
Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector T H 2 subsets Jun 2018 [Burks]
Tree nut allergies: Allergen homology, cross-reactivity, and implications for therapy Jun 2018 [Kulis, Smeekens]
Characteristics of Preschool-Aged Children Currently Enrolled in a Phase II Double Blind Placebo Controlled Study of Peanut Sublingual Immunotherapy Feb 2018 [Burks, Herlihy, Kim]
A novel assessment of sustained unresponsiveness (SU) after long term sublingual immunotherapy (SLIT) in peanut allergic children: results of a 4 year phase II clinical trial Feb 2018 [Bennick, Burks, Hamilton, Herlihy, Kim]
Assessing the validity of an IRB approved REDCap web based clinical trials recruitment registry Feb 2018 [Bennick, English, Hamilton, Herlihy, Kim]
2017
Immune mechanisms of oral immunotherapy Dec 2017 [Kulis]
Characterization of the B-cell receptor repertoires in peanut allergic subjects undergoing oral immunotherapy Nov 2017 [Burks, Kulis]
Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model Sep 2017 [Kulis]
Effect of endotoxin and alum adjuvant vaccine on peanut allergy Sep 2017 [Burks, Kulis]
Specific allergen profiles of peanut foods and diagnostic or therapeutic allergenic products Jul 2017 [Commins, Kulis]
Controlled Asthma Not Correlated with Respiratory Symptoms During DBPCFCs (Double Blind Placebo Controlled Food Challenges) to Peanut in Children Feb 2017 [Bennick, Hamilton, Herlihy, Kim]
Sublingual Peanut Immunotherapy: Role of Duration and Dose. Feb 2017 [Bennick, Burks, Hamilton, Herlihy, Kim]
Sustained Unresponsiveness After Sublingual Immunotherapy for Peanut-allergic Children Feb 2017 [Bennick, Burks, Hamilton, Herlihy, Kim]
Preparation and Analysis of Peanut Flour Used in Oral Immunotherapy Clinical Trials Jan 2017 [ Burks, Kesselring, Kulis, Penumarti]
2016
Eosinophilic esophagitis during peanut oral immunotherapy with omalizumab Dec 2016 [Burks, Kulis]
Food allergen extracts to diagnose food-induced allergic diseases: How they are made Nov 2016 [Burks, Penumarti]
Mast cell desensitization inhibits calcium flux and aberrantly remodels actin Sep 2016 [Burks, Kulis]
Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2 Aug 2016 [Burks, Kulis]
Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective Aug 2016 [Burks, Guo, Kim, Kulis, Ye]
Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness Jun 2016 [Burks, Kulis]
Peanut Allergy: New Developments and Clinical Implications May 2016 [Commins, Kim, Kulis]
The Seed Biotinylated Protein of Soybean (Glycine max): A Boiling-Resistant New Allergen (Gly m 7) with the Capacity To Induce IgE-Mediated Allergic Responses May 2016 [Burks, Kulis]
Food-specific IgG 4 is associated with eosinophilic esophagitis Apr 2016 [Burks, Guo, Kulis]
NMR-Based Metabolomics Analysis Reproducibly Identifies Unique Subject-Specific Profiles That Change during Peanut Oral Immunotherapy Feb 2016 [Burks, Hamilton, Kulis]
Basophil Activation and Peanut-Specific IgE Are Not Predictors of Threshold Dose during a Double-Blind Placebo-Controlled Food Challenge (DBPCFC) Feb 2016 [Burks, Guo, Hamilton, Kim, Ye]
Utility of component analyses in subjects undergoing sublingual immunotherapy for peanut allergy Feb 2016 [Burks, Kim, Kulis]
2015
High Rate of Sustained Unresponsiveness with Early-Intervention Peanut Oral Immunotherapy Feb 2015 [Burks, Hamilton, Herlihy, Kim, Kulis]
Peanut Sublingual Immunotherapy (SLIT) Results in Sustained Unresponsiveness in a Subset of Peanut Allergic Children Feb 2015 [Burks, Hamilton, Guo, Kim, Kulis]
Basophil Hyporesponsiveness Following Six Months of Peanut Oral Immunotherapy (OIT) Is Associated with Suppression of Syk Phosphorylation Feb 2015 [Burks, Hamilton, Kulis, Yue]
2014
Novel strategy to create hypoallergenic peanut protein-polyphenol edible matrices for oral immunotherapy May 2014 [Burks, Guo, Kulis]
Prior to 2014
Allergenic properties of enzymatically hydrolyzed peanut flour extracts Jul 2013 [Burks, Guo, Kulis]
Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy Jul 2012 [Burks, Guo, Kulis]
A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response Mar 2011 [Burks, Kulis, Yue]