UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.
Dr. David Lawrence Scientists at the University of North Carolina at Chapel Hill have developed a breakthrough technique that uses light to activate a drug stored in circulating red blood cells so that it is released exactly when and where it is needed. The work, led by Fred Eshelman Distinguished Professor David Lawrence in … Read more
UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is “Engineering extrinsic disorder to control protein activity in living cells.”
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“Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory,”Winkle and Olsen, et al., J. Neuroscience, 36(18): 4940-4958, 2016.
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“Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus.” Song et al., Nature Neuroscience 16: 1728-1730, 2013.
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“Follow-Up After Gene Therapy for Canavan Disease.” Leone et al., Science Translational Medicine Vol. 4, Issue 165, p. 165ra163, 2012. DOI: 10.1126/scitranslmed.3003454. doi:10.1038/nsmb.2377.
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“Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota.” Arthur et al., Science 338 (6103): 120-123, 2012. doi:10.1038/nsmb.2377.
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“Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules.” Nature Struct Mol Biol., published online doi:10.1038/nsmb.2377.
