We are happy to announce the promotion of Dr. Nicholas Brown to the rank of Associate Professor, effective September 29th, 2023!
![Dr. Nicholas G. Brown, Associate Professor with tenure at UNC Pharmacology](https://www.med.unc.edu/pharm/wp-content/uploads/sites/930/2023/10/IMG_6582-scaled-e1696802350232-300x300.jpg)
We thank Nick for his dedication and contributions to the department and congratulate him on this well-deserved promotion.
Research at the Brown Lab centers around unraveling the intricate system of inter- and intra-molecular interactions that dynamically regulate the catalytic mechanisms of enzymes, with a specific focus on their roles in the cell cycle. Their research approach has been truly interdisciplinary, combining techniques such as enzyme kinetics, mutagenesis, X-ray crystallography, NMR spectroscopy, and cryogenic electron microscopy (cryo-EM) to characterize these molecular machines. Their recent paper in Nature Structural & Molecular Biology, employing time-resolved cryogenic cryo-EM and Deep Reconstructing Generative Networks (cryoDRGN), unveiled the specific mechanisms of APC/C – a crucial protein complex involved in substrate polyubiquitination. The Brown Lab’s work provides invaluable mechanistic insights into the cell cycle, with future implications for the design of cancer therapeutics.
~ Read more on the recent Nature Structural & Molecular Biology publication by the Brown Lab