Author Archives: samweiss
Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
This study used machine learning methods to examine features from 26 posttraumatic symptoms assessed during the first 8 weeks following traumatic exposure in order to develop a pragmatic algorithm to predict PTSD. The resulting algorithm accurately predicted PTSD and contained the mean scores from three items: nervousness, re-hashing, and fatigue.
A Curriculum on Digital Psychiatry for a US-Based Psychiatry Residency Training Program: Pilot Implementation Study
This pilot implementation study outlines a curriculum on digital psychiatry at a large US-based psychiatry residency training program, including an evaluation of learner confidence in the appraisal and clinical recommendation of digital mental health apps.
ShapeAXI: Shape Analysis Explainability and Interpretability
ShapeAXI is a framework for shape analysis that uses a multi-view approach, capturing 3D objects from various angles and analyzing them with 2D CNNs. It features an automatic N-fold cross-validation process and generates explainability heat-maps, demonstrating its effectiveness in classifying condyles and cleft patient shapes, with its implementation available on GitHub.
Development of a brief bedside tool to screen women sexual assault survivors for risk of persistent posttraumatic stress six months after sexual assault
The current study developed and validated a brief bedside screening tool that could be used with recent sexual assault survivors to understand who is at risk for chronic and impairing posttraumatic stress (PTS) and could benefit from early intervention. The sample included 547 women presenting to one of thirteen hospitals across the US for acute … Read more
A method for estimating dynamic functional network connectivity gradients (dFNG) from ICA captures smooth inter- network modulation
Dynamic functional network connectivity (dFNC) analysis is a widely used approach for studying brain function and offering insight into how brain networks evolve over time. Functional dysconnectivity between different brain regions has been reported in schizophrenia, yet the neural mechanisms behind it remain elusive. This manuscript presents a complementary novel approach that optimizes FNC, as … Read more
Predator odor stress reactivity, alcohol drinking and the endocannabinoid system
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid and individual differences in response to stress suggest resilient and susceptible populations. The current review discusses the advantages of using predator odor stressors to better understand PTSD pathophysiology and neurobiological mechanisms associated with stress reactivity and subsequent increases in alcohol drinking. In addition, … Read more
Internal Representations Are Prioritized by Frontoparietal Theta Connectivity and Suppressed by alpha Oscillation Dynamics: Evidence from Concurrent Transcranial Magnetic Stimulation EEG and Invasive EEG
Control over internal representations requires the prioritization of relevant information and suppression of irrelevant information. We used TMS while participants either prioritized or suppressed information during a working memory task. We found evidence to support the idea that the frontoparietal theta network prioritizes internally maintained representations and alpha oscillations in the posterior parietal cortex suppress … Read more
Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders
This review emphasizes the significant therapeutic potential of neuroactive steroids in modulating TLR signaling pathways, particularly in addressing inflammatory processes associated with neuropsychiatric disorders. It advances our understanding of the complex interplay between neuroactive steroids and immune responses, paving the way for personalized treatment strategies tailored to individual needs and providing insights for future research … Read more