Author Archives: samweiss
From Disparities to Equity: Striving for More in our Treatments for Eating Disorders
Adopting a framework of equity is urgently needed to reduce disparities persistent in feeding and eating disorder (FED) treatment models. This framework must emphasize the exchange of knowledge between relevant stakeholders and implementation strategies to impact practice and embrace a systemic change in the FED field.
Neurosteroid [3α,5α]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway
The results demonstrate neurosteroid allopregnanolone enhancement of the endosomal TLR4-TRIF anti-inflammatory signals and elevations of IL-10 in male P rat brain that were not detected in female P rat brain. These anti-inflammatory signals are neuroprotective and counter inflammatory signals that are common in alcohol use disorders and depression. The data hold significant implications for controlling … Read more
Are the diagnostic rates of autistic females increasing? An examination of state-wide trends
An examination of 20 years of clinical data indicate that diagnosis of autism in females has increased over the years, likely reflecting greater knowledge of how autism presents in females.
Enlarged Perivascular Spaces in Infancy and Autism Diagnosis, Cerebrospinal Fluid Volume, and Later Sleep Problems
In this study, enlarged perivascular spaces at 24 months of age were associated with autism diagnosis, excessive cerebrospinal fluid volume, and later sleep problems. Findings suggest the glymphatic system may be dysregulated in infants who develop autism.
Epigenetic Age Acceleration as a Biomarker for Impaired Cognitive Abilities in Adulthood Following Early Life Adversity and Psychiatric Disorders
Age-related decline is observed across multiple neurocognitive domains. Normative cognitive aging may be accelerated by a history of early life adversity and psychiatric disorders. The present results provide evidence that epigenetic age acceleration have the potential to serve as a biomarker for cognitive decline in patients with a child maltreatment history or psychiatric disorders