Recent Publications
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Probing the neurocardiac circuit in trauma and posttraumatic stress
This study probed the neurocardiac circuit by examining associations among its core regions in the brain (e.g., hypothalamus) and the periphery (heart rate [HR], high frequency heart rate variability [HF-HRV], and blood pressure [BP]). Participants were 315 trauma-exposed adults enrolled from emergency departments as part of the prospective AURORA study. Among those with PTSD, lower … Read more
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Polygenic risk, childhood abuse and gene x environment interactions with depression development from middle to late adulthood: A U.S. national life-course study.
Utilizing national longitudinal data, this study examined how polygenic depression risk and childhood abuse interactively influence the life-course development of depressive conditions from middle to late adulthood. The results revealed that Increasing polygenic depression scores were associated with elevated CES-D levels and potential risks of clinical depression. Non-maltreated females generally exhibited higher depressive symptoms and … Read more
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A novel method for quantifying affective sensitivity to endogenous ovarian hormones
Increased sensitivity to ovarian hormone changes is implicated in the etiology of reproductive mood disorders across the female lifespan, including menstrually-related mood disorders, perinatal mood disorders, and perimenopausal depression. We developed a novel method to accurately quantify sensitivity to endogenous hormone fluctuations that may facilitate the prediction and prevention of these mental health conditions.
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Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery
This work highlights the utility of prefrontomotor cross-frequency coupling as a potential motor status and recovery biomarker in stroke. The frequency- and region-specific neurocircuitry featured in this work may also facilitate novel treatment strategies in stroke.
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The effects of psychotherapy for anhedonia on subcortical brain volumes measured with ultra-high field MRI
This exploratory analysis examined the effects of psychotherapy on subcortical brain volumes. Psychotherapy for anhedonia was not accompanied by changes in subcortical brain volumes. However, there was a modest relation between pre-treatment anhedonia and change in caudate nucleus volumes during treatment.
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Ferret as a model system for studying the anatomy and function of the prefrontal cortex: A systematic review
Here, we provide a summary of all published research pertaining to the frontal and/or prefrontal cortex of the ferret across research scales. By doing so, we hope to improve clarity in the interpretation of both previous and future publications on the comparative study of frontal cortex.
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Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
This study used machine learning methods to examine features from 26 posttraumatic symptoms assessed during the first 8 weeks following traumatic exposure in order to develop a pragmatic algorithm to predict PTSD. The resulting algorithm accurately predicted PTSD and contained the mean scores from three items: nervousness, re-hashing, and fatigue.
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A Curriculum on Digital Psychiatry for a US-Based Psychiatry Residency Training Program: Pilot Implementation Study
This pilot implementation study outlines a curriculum on digital psychiatry at a large US-based psychiatry residency training program, including an evaluation of learner confidence in the appraisal and clinical recommendation of digital mental health apps.
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ShapeAXI: Shape Analysis Explainability and Interpretability
ShapeAXI is a framework for shape analysis that uses a multi-view approach, capturing 3D objects from various angles and analyzing them with 2D CNNs. It features an automatic N-fold cross-validation process and generates explainability heat-maps, demonstrating its effectiveness in classifying condyles and cleft patient shapes, with its implementation available on GitHub.
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Development of a brief bedside tool to screen women sexual assault survivors for risk of persistent posttraumatic stress six months after sexual assault
The current study developed and validated a brief bedside screening tool that could be used with recent sexual assault survivors to understand who is at risk for chronic and impairing posttraumatic stress (PTS) and could benefit from early intervention. The sample included 547 women presenting to one of thirteen hospitals across the US for acute … Read more