Fibrinogen synthesis and expression

Fibrinogen synthesis and expression. Fibrinogen synthesis is regulated by both transcriptional and translational mechanisms. After individual fibrinogen chains are translated, fibrinogen assembly occurs stepwise. Single chains assemble first into Aα-γ and Bβ-γ precursors, then into Aα/Bβ/γ half-molecules, and finally into hexameric complexes (Aα/Bβ/γ)2. Once fibrinogen is released into blood, it circulates until thrombin cleaves fibrinopeptides from the Aα and Bβ chains (FpA and FpB, respectively) to form fibrin monomers. These monomers then polymerize in a half-staggered arrangement to form fibrin protofibrils and ultimately the fibrin network at a site of tissue injury.