2023

Zhao, S., Lu, J., Pan, B., Fan, H., Byrum, S. D., Xu, C., Kim, A., Guo, Y., Kanchi, K. L., Gong, W., Sun, T., Storey, A. J., Burkholder, N. T., Mackintosh, S. G., Kuhlers, P. C., Edmondson, R. D., Strahl, B. D., Diao, Y., Tackett, A. J., Raab, J. R., Cai. L., Song, J. & Wang, G. G. (2023) TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. doi: 10.1038/s41586-023-06688-z.

Muneer, A., Wang, L., Xie, L., Zhnag, F., Wu, B., Mei, L., Lenarcic, E., M., Feng., E. H., Song, J., Xiong, Y., Yu, X., Wang, C., Jian, K., Strahl, B. D., Cook, J. G., Wan, Y. Y., Moorman, N. J., Song, H., Jin, J. & Chen, X. (2023) Functional multi-omics reveals noncanonical function of G9a in the protein-specific translation regulation of chronic inflammation. Cell Chem Biol. S2451-9456(23)00331-8.

Mason, F. M., Kounlavong, E. S., Tebeje, A. T., Dahiya, R., Guess, T., Khan, A., Vlach, L., Norris, S. R., Lovejoy, C. A., Dere, R., Strahl, B. D., Ohi, R., Ly, P., Walker, C. L. & Rathmell, K. W. (2023) SETD2 safeguards the genome against isochromosome formation. Proc Natl Acad Sci. 120: e2303752120.

Petell, C. J., Burkholder, N. T., Ruiz, P., Skela, J., Foreman, J.R., Southwell, L. E., Temple, B. R., Krajewski, K. & Strahl, B. D. (2023) The BAH domains of PBRM1 associate histone histone tails and contribute to PBAF-mediated gene regulation. J Biol Chem. 299:104996.

Chen, Z.*, Lundy, T.*, Zhu, Z., Zhang, J., Yao, Y. Hoskins, V. E., Strahl, B. D.* & Xu, C.* Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4. Cell Discov. 9:51.

Jain, K., Marunde, M. R., Burg, J. M., Gloor, S. L., Joseph, F. M., Ponch, K. F., Gillespie, Z. B., Rodriguez, K. L., Popova, I. K., Popova, I. K., Hall, N. W., Vaidya, A., Howard, S. A., Taylor, H. F., Mukhsinova, L., Onuoha, U. C., Patteson, E. F., Cooke, S. W., Taylor, B. C., Weinzapefel, E. N., Cheek, M. A., Meiners, M. J., Fox, G. C., Namitz, K. E. W., Cowles, M. W., Krajewski, K., Sun, Z. W., Cosgrove, M. S., Young, N. L., Keogh, M.C.* & Strahl, B. D.* (2023) An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability. ELife. 12:e82596.

Jain, K. & Strahl, B. D. (2023) In Memoriam C. David Allis: Chromatin unlocked. Nat Rev Molecular Cell Biol. 24:311.

Nguyen, M. C., Strahl, B. D. & Kutateladze, T., G. Engaging with benzoyllysine through a π-π-π mechanism. (2023) Curr Opin Chem Biol. 72:102252.

2022

Liu, X., Wang, J., Boyer, J. A., Gong, W., Zhao, S., Xie, L., Wu, Q., Zhang, C., Jain, K., Guo, Y., Rodriguez, J., Li, M., Uryu, H., Liao, C., Hu, L., Zhou, J., Shi, X., Tsai, Y.-H., Yan, Q., Luo, W., Chen X., Strahl, B. D., Kriegsheim, A. V., Zhang Q., Wang, G. G., Baldwin, A. S. & Zhang Q. (2022) Histone H3 hydroxylation regulates gene expression in mammalian cells. Nature Genetics. 54:1721-1735.

Klein, B. J, Feigerle, J. T., Zhnag, J., Ebmeier, C. C., Fan, L., Singh, R. K., Wang, W. W., Schmitt, L. R., Lee, T., Hansen, K. C., Liu, W. R., Wang, Y-.X., Strahl, B. D., Weil, P. A., Kornberg, R., D. & Kutateladze, T., G. (2022) Taf2 mediates DNA binding of Taf14. Nat Commun. 13:3177.

Niedzialkowska, E., Liu, L., Kuscu, C., Mayo, Z., Minor, W., Strahl, B. D., ldi, M. & Stukenberg, P. T. (2022) Tip60 acetylation of histone H3K4 temporally controls Chromosome Passenger Complex localization. Mol Biol Cell. mbcE21060283.

Tencer, A. H., Liu, J., Zhu, J., Burkholder, N. T., Zhang, Y, Wu, W., Strahl, B. D., Ohta T. & Kutateladze, T. G. (2022) The ZZ domain of HERC2 is a receptor of arginylated substrates. Scientific Reports. 12:6063.

Crain, A. T., Klusza, S., Armstrong, R. L., Rosa, P. S., Temple, B. R. S., Strahl, B. D., McKay, D. J., Matera, A. G. & Duronio, R. J. (2022) Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster. Genetics. 221:iyac054.

Falcinelli, S. D., Peterson, J. J., Turner, A.-M. W., Irlbeck, D., Read, J., Raines, S. L. M., James, K. S., Sutton, C., Sanchez, A., Emery, A., Sampey, G., Ferris, R., Allard, B., Ghofrani, S., Kirchherr, J., Baker, C., Kuruc, D., J., Gay, C. L., James, L. I., Wu, G., Zuck, P., Rioja, I., Furze, R. C., Prinjha, R. K., Howell, B., Swanstrom, R., Browne, E. P., Strahl, B. D., Dunham, R. M., Archin, N. M. & Margolis, D. (2022) Combined non-canonical NF-κB agonism and targeted BET bromodomain inhibition reverses HIV latency ex vivo. J Clin Invest. 132:e157281.

2021

Zhang, J., Gundu, A. & Strahl, B. D. (2021) Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Genes & Dev. 35:1678-1692.

Petell, C., J., Randene, K., Pappas, M., Sandoval, D., Strahl, B. D., Harrison, J. S. & Steimel, J. P. (2021) Measuring biological interactions with magnetic probes. ELife. 10:e67525.

Enríquez, P., Krajewski, K., Strahl, B. D., Rothbart, S. B., Dowen, R. H. & Rose, R. B. (2021) Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain with acetylated histone H3K14. J Biol Chem.297:101145.

Yoblinski, A. R., Forester, K., E., Chung, S., Robinson, Strahl, B. D.* & Dronamraju, R.* Catalysis-Dependent and Redundant Roles of Dma1 and Dma2 in Maintenance of Genome Stability in Saccharomyces cerevisiae. J Biol Chem. 296:100721.

Ren, W., Fan, H., Grimm, S., Kim, J. J., Li, L., Guo, Y., Petell, C. Tan, X.-F., Zhnag, Z.-M., Coan, J., Yin, J., Kim, D. I., Gao, L., Cai, L., Khudaverdyan, N. N., Cetin, B., Patel, D., Wang, Y., Cui, Q., Strahl, B. D. , Gozani, O., Miller, K., O’leary, S., Wade, P., Wang, G. G. & Song, J. (2021) DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Nature Communications. 12:2490.

Jain, K & Strahl, B. D. (2021) Oncohistones: corruption at the core. Nat Chem Biol. 17:370-371.

Slaughter, M. J., Shanle, E. K., Khan, A., Chua, K. F., Hong, T., Boxer, L. D., Allis, C. D., Josefowicz, S. Z., Garcia, B. A., Rothbart, S. B, Strahl, B. D.* & Davis, I. J.* (2021) HDAC inhibitors result in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Cell Reports. 34:108638.

2020

Braberg, H., Echeverria, I, Bohn, S., Cimermancic, P., Shiver, A., Alexander, R., Xu, J., Shales, M., Dronamraju, R., Jiang, S., Dwivedi, G., Bogdanoff, D., Chaung, K. K., Huettenhain, R., Wang, S., Mavor, D., Pellarin, R., Schneidman, D., Bader, J. S., Fraser, J. S., Morris, J., Haber, J. E., Strahl, B. D., Gross, C. A., Dai, J., Boeke, J., Sali, A & Krogan, N. J. (2020) Genetic interaction mapping informs integrative structure determination of protein complexes. Science. doi: 10.1126/science.aaz4910.

Fan, H., Lu, J., Guo, Y., Li, D., Zhang, Z., Tsai, Y-H., Pi, W-C., Ahn. J. H., Gong, W., Xiang, Y., Allison, D. F., Geng, H., He, S., Diao, Y., Chen, W.-Y., Strahl, B. D. , Cai, L. Song, J. & Wang, G. G. (2020) BAHCC1 couples H3K27me3 to gene silencing and tumorigenesis via a conserved BAH module. Nature Genetics. 52:1384-1396.

Tencer, A. H., Cox, K. L., Wright, G. M., Zhang, Y., Klein, B. J., Petell, C. J., Strahl, B. D., Black, J. C., Poireir, M. G. & Kutateladze, T. G. (2020) Molecular mechanism of the MORC4 ATPase activation. Nature Communications. 11:5466

Vaughan, R. M., Kupai, A., Foley, C. A., Sagum, C. A., Tibben, B. M., Eden, H. E., Tiedemann, R. L., Berryhill, C. A., Patel, V., Shaw, K., M., Krajewski, K., Strahl, B. D., Bedford, M., T., Frye, S., V., Dickson, B. D. & Rothbart, S., B. (2020) The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells. Epigenetics & Chromatin. 13:44.

Lerner, A. M.*, Hepperla, A. J.*, Keele, G. R.*, Meriesh, H., Yumerefendi, H., Restrepo, D., Zimmerman, S., Bear, J., Kuhlman, B., Davis, I. J.* & Strahl B. D.* (2020) An optogenetic switch for the Set2 methyltransferase provides evidence for rapid transcription-dependent and independent dynamics of H3K36 methylation. Genome Research. 30:1605-1617.

Ren, W., Fan, H., Grimm, S. A., Guo, Y., Kim, J. J., Li, L., Petell, C. J., Tan, X.-F., Zhang, Z.-M., Coan, J. P., Gao, L., Cai, L., Detrick, B., Cetin, B., Cui, Q., Strahl, B. D., Gozani, O., Wang, Y., Miller, K. M., O’leary, S., Wade, P. A., Wang, G. G. & Song, Jikui. (2020) Direct readout of heterochromatin H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proc Natl Acad Sci. doi: 10.1073/pnas.2009316117.

Strahl, B. D. & Briggs S. D. (2020) The SAGA continues: The rise of cis- and trans-histone crosstalk pathways. Biochim Biophys Acta Gene Regul Mech. doi: 10.1016/j.bbagrm.2020.194600.

DiFiore, J. V., Ptacek, T. S., Li, B., Simon, J. M. & Strahl, B. D. (2020) Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions. Cell Reports.31:107751.

Turner, A.-M., Dronamraju, R., Potjewyd, F. M., Sholtis, K., M., Winecoff, D. K., Kirchherr, J. L., Archin, N. M., Browne, E. P., Strahl, B. D., James, Lindsey, I & Margolis, D. M. (2020) Evaluation of EED Inhibitors as a New Class of PRC2-Targeted Small Molecules for HIV Latency Reversal. ACS Infectious Diseases. doi: 10.1021/acsinfecdis.9b00514.

Meriesh, H. A., Lerner, A. M., Chandrasekharan, M. B. & Strahl, B. D. (2020) The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation. J Biol Chem. 295:6561-6569.

Jian, K., Frase, C. S., Marunde, M., Parker, M. M., Sagum, C., Burg, J., Hall, N., Popov, I., Rodriguez, K., Vadiya, A., Krajewski, K., Keogh, M.-C., Bedford, M. T*. & Strahl, B. D.* (2020) Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions. Epigenetics & Chromatin. 13:3.

2019

Gowans, G. J., Bridgers, J. B., Zhang, J., Dronamraju, R., Burnetti, A., King, D. A., Thiengmany, A. V., Shinsky, S. A., Bhanu, N. V., Garcia, B. A., Buchler, N. E., Strahl, B. D.* & Morrison, A. J.* (2019) Recognition of histone crotonylation by Taf14 links metabolic state to gene expression. Molecular Cell. 76:909-921.

Albanese, K. I.*, Krone, M. W.*, Petell, C. J.*, Parker, M. M., Strahl B. D., Brustad, E. M. & Waters, M. L. (2019) Engineered reader proteins for enhanced detection of methylated lysine on histones. ACS Chem Biol. doi: 10.1021/acschembio.9b00651.

Li, T.M., Coan, J. P., Krajewski, K., Zhang, L., Elias, J. E., Strahl, B. D., Gozani, O & Chua, KF. (2019) Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. Sci Rep. 9:14226.

Klein, B. J., Jang, S. M., Lachance C., Mi, W., Sakuraba, S., Krajewski, K., Lyu, J., Wang, W. W., Sidoli, S., Yan, K., Liu, J., Zhang, Y., Roques, C., Fournier, E., Wang, X., Warfield, B. M., Yang, X.0J., Garcia, B. A., Liu, W. R., Li, W., Strahl, B. D., Kono, H., Shi, X., Cote, J. & Kutateladze. (2019) Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Nature Commun. 10:4724.

Zhang, Y., Jang, Y., Lee, J.-E., Ahn, J., Xu, L., Holden, M. R., Cornett, E. M., Krajewski, K., Klein, B. J., Wang, S.-P., Dou, Y., Roeder, R. G., Strahl, B. D., Rothbart, S. B., Shi, X., Ge, K. & Kutateladze, T. G. (2019) Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.  Nature Commun. 10:2314.

Petell, C. J., Pham, A. T., Skela, J. & Strahl, B. D. Improved methods for the detection of histone interactions with peptide microarrays.  Sci Rep. 9:6265.

Noubouossie D. F., Reeves, B. N., Strahl, B. D. & Key, N. S. (2019) Neutrophils: back in the thrombosis spotlight. Blood doi: 10.1182/blood-2018-10-862243.

Armstrong, R. L., Penke, T. J. R., Chao, S. K., Gentile, G. M., Strahl, B. D., Matera, A. G., McKay, D. J. & Duronio, R. J. (2019) H3K9 promotes under-replication of pericentromeric heterochromatin in Drosophila salivary gland polytene chromosomes. Genes. 10(2) E93.

Leatham-Jensen, M., Uyehara, C. M., Strahl, B. D., Matera, A. G., Duronio, R. J. & McKay, D., J. (2019) Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation. PLoS Genet. 15:e1007932.

2018

Dranamraju, R., Kerschner, J. L., Peck, S. A., Patel, D., Aslam, S., Mosley, A. L. & Strahl, B. D. (2018) Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction.  Cell Reports. 25:3476-3489.

Lerner, A. M., Yumerefendi, H., Goudy, O. J., Strahl, B. D. & Kuhlman K. (2018) Engineering improved photoswitches for the control of nucleocytoplasmic distribution.  ACS Synthetic Biology. 0.1021/acssynbio.8b00368.

Klein, B.J.,Vann, K. R., Andrews, F. H., Wang, W. W, Zhang, J., Zhang, Y., Beloglazkina, A. A., Mi, W., Li, Yuanyuan, Li., H., Shi, X., Kutateladze, A. G., Strahl, B. D., Liu, W. R. & Kutateladze, T. G. (2018) Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain. Nature Commun. 9:4574.

Klein, B.J., Krajewski, K., Restrepo, S., Lewis, P. W.*, Strahl, B. D.* & Kutateladze, T. G.* (2018) Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers. Epigenetics. doi: 10.1080/15592294.2018.1503491.

Slaughter, M. J., Shanle, E. K., McFadden, A. W., Suttle, L. E., Strahl, B. D. & Davis, I. J. (2018) Polybromo-1 (PBRM1) bromodomains variably influence nucleosome interactions and cellular function. J Biol Chem. doi: 10.1074/jbc.RA118.003381.

Dronamraju, R., Hepperla, A. J., Shibata, Y., Adams, A. T., Magnuson, T., Davis, I. J. & Strahl, B. D. (2018) Spt6 association with RNA Polymerase II directs mRNA turnover during transcription. Molecular Cell. 70:1054-1066

Chiang, Y. C., Park, I. Y., Terzo, E. A., Tripathi, D. N., Mason, F. M., Fahey, C. C., Karki, M., Shuster, C. B., Sohn, B., H., Chowdhary, P., Powell, R. T., Ohi, R., Tsai, Y. S., de Cubas, A. A., Khan, A., Davis, I. J., Strahl, B. D., Parker, J. S., Dere, R., Walker, C. L. & Rathmell, W. K. (2018) SET2 haploinsufficiency for microtubule methylation is an early driver of genomic instability in renal cell carcinoma. Cancer Research. 78:3135-3146.

Suh, J. L., Watts, B., Stuckey, J. I., Norris-Drouin, J. L., Cholensky, S. H., Dickson, B. M., An, Y., Mathea, S., Knapp, S., Khan, A., Adams, A. T., Strahl, B. D., Sagum, C., Bedford, M. T., James, L. I., Kireev, D. B. & Frye, S. V. (2018) Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1. Biochemistry. 57:2140-2149.

Meers, M. P., Aldemna, K., Duronio, R. J., Strahl, B. D., McKay, D. J. & Matera, A. G. (2018) Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster. BMC Genomics. 19:157.

Dronamraju, R., Jha, D., Eser, E., Dominguez, D., Adams, A., Choudhury, R., Chiang, Y. C., Rathmell, W. K., Emanuele, M. J., Churchman, L. S. & Strahl, B. D. (2018) Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity. Nucleic Acids Research. 46:1331-1334.

Klein, B. J., Ahmad, S., Vann, K. R., Andrews, F. H., Mayo, Z. A., Bourriquen, G., Bridgers, J. B., Zhang, J., Strahl, B. D., Cote, J. & Kutateladze, T. G. (2018) Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic Acids Research. 46:421-430.

Penke, T., McKay, D. J., Strahl, B. D., Matera, A. G. & Duronio, R. J. (2018) Functional redundancy of variant and canonical histone H3 lysine 9 modification in Drosophila. Genetics. 208:229-244.

2017

Veland, N., Zhong, Y., Gayatri, S., Dan, J, Strahl, B. D., Rothbart, S. B., Bedford, M. T. & Chen T. The arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in cancer. Cell Reports. 21:3390-3397.

Tencer, A. H., Cox, K. L., Di, L., Bridgers, J. B., Lyu, J., Wang, X., Sims, J. K., Weaver, T. M., Allen, H. F., Zhang, Y., Gatchalian, J., Darcy, M. A., Gibson, M. D., Ikebe, J., Li, W., Wade, P. A., Hayes, J. J., Strahl, B. D., Kono, H., Poirier, M. G., Musselman, C. A. & Kutateladze, T. G. (2017) Covalent modification of histone H3K9 promotes binding of CHD3. Cell Reports. 21:455-466.

Dronamraju, R.*, Ramachandran, S.*, Jha, D. K.*, Adams, A. T., DiFiore, J. V., Parra, M. A., Dokholyan, N. V.* & Strahl, B. D.* (2017) Redundant functions for Nap1 and Chz1 in H2A.Z deposition. Scientific Reports. 7:10791.

Tencer, A. H., Gatchalian, J., Klein, B. J., Khan, A., Zhang, Y., van Wely, K. H. M., Strahl, B. D. & Kutateladze, T. G. (2017) A unique pH-dependent recognition of methylated histone H3K4 by PPS and DIDO3. Structure. 25:1530-1539.

McDaniel, S. L., Hepperla, A., Huang, Jie, Kulkarni, V. G., Davis, I. J. & Strahl, B. D. (2017) H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity. Cell Reports. 19:2371-2382

McDaniel, S. L. & Strahl, B. D. (2017) Shaping the Cellular Landscape with Set2/SETD2 methylation. Cellular & Molecular Life Sciences. doi: 10.1007/s00018-017-2517-x.

Khan, A., Bridgers, J. S. & Strahl, B. D. (2017) Expanding the reader landscape of histone acylation. Structure. 25:571-573.

Meers, M., P., Henriques, T., Lavender, C. A., McKay, D. J., Strahl, B. D., Duronio, R. J., Adelman, K. & Matera, A. G. (2017) Histone replacement decouples H4 acetylation from cryptic transcription in H3K6 mutants and reveals a post-transcriptional mechanism for maintaining transcriptome fidelity in animals. ELife. pii: e23249. doi: 10.7554/eLife.23249.

Shanle, E. K.*, Shinsky, A. A.*, Bridgers, J. B., Bae, N., Sagum, C., Krajewski, K., Rothbart, S. B., Bedford, M. T.* & Strahl, B. D.* (2017) Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics & Chromatin. 10:12 doi: 10.1186/s13072-017-0117-5.

Select Papers From 2016 and Earlier

Strikoudis, A., Lazaris, C., Trimarchi, T., Galvao Neto, A. L., Yang, Y., Ntziachristos, P., Rothbart, S. D., Buckley, S., Dolgalev, I., Stadtfeld, M., Strahl, B. D., Dynlacht, B. D., Tsirigos, A & Aifantis, I. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature Cell Biology. doi: 10.1038/ncb3424.

Hacker, K. E.*, Fahey, C. C.*, Shinsky, S. A.*, Chiang, Y.-C. J.*, DiFiore, J. V.*, Jha, D. K., Vo, A. H., Shavit, J. A. Davis, I, J., Strahl, B. D.* & Rathmell, W. K.* (2016) Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. Journal of Biological Chemistry. Aug 15. pii: jbc.M116.739375.

McDaniel, S. L., Fligor, J. E., Chun, R., Cui, H., Bridgers, J. B., DiFiore, J. V., Guo, A. H., Li, B. & Strahl, B. D. (2016) Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity. Journal of Biological Chemistry. 291:14796-14802.

Yumerefendi, H., Lerner, A. M., Zimmerman, S. P., Hahn, K., Bear, J. E., Strahl, B. D. & Kuhlman, B. (2016) Light-induced nuclear export reveals rapid dynamics of epigenetic marks. Nature Chemical Biology. 12:399-401.

Andrews, F. H.*, Shinsky, A. S.*, Shanle, E. K., Bridgers, J. B., Gest, A., Tsun, I. K., Krajewski, K., Shi, X., Strahl, B. D.* & Kutateladze, T. G.* (2016) The Taf14 YEATS domain is a reader of histone crotonylation. Nature Chemical Biology. 12:396-398.

Andrews, F. H.*, Shanle, E. K.*, Strahl, B. D.* & Kutateladze, T. G.* (2016) The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation. Transcription. 7:14-20.

Shanle, E. K., Tsun, I. K. & Strahl, B. D. (2016) A course-based undergraduate research experience investigating p300 bromodomain mutations. Biochemistry and Molecular Biology Education. 44:68-74.

Shanle, E. K, Andrews, F. H., Meriesh, H., McDaniel, S. L., Dronamraiu, R., DiFiore J., Jha, D., Wozniak, G. G., Bridgers, J., Kerschner, J. L., Martin, G. M., Morrison A. J., Krajewski, K., Kutateladze, T*. & Strahl, B. D.* (2015) Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Genes & Development. 29:1789-1794.

Rothbart, S. B., Dickson, B. M., Raab, J. R., Grzybowski, A. T., Krajewski, K., Guo, A. H., Shanle, E. K., Josefowicz, S. Z., Fuchs, S. M., Allis, C. D., Magnuson, T. R., Ruthenburg, A. J. & Strahl, B. D. (2015) An interactive database for the assessment of histone antibody specificity. Molecular Cell. 59:502-511.

McKay, D. J., Klusza, S., Penke, T. J., R., Meers, M. P., Curry, K. P., McDaniel, S. L., Malek, P. Y., Cooper, S. W., Tatomer, D., C., Lieb, J. D., Strahl, B. D., Duronio, R. J. & Matera, A. G. (2015) Interrogating the function of metazoan histones using engineered gene clusters. Developmental Cell. 32:373-86.

Dumesic, P. A., Homer, C. M., Moresco, J. J., Pack, L. R., Shanle, E. K., Coyle, S. M., Strahl, B. D., Fujimori, D. G., Yates, J. R. & Madhani, H. D. (2015) Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell. 160:1-15.

Gilbert, T. M.*, McDaniel, S. L.*, Byrum., S. D., Cades, J. A., Dancy, B. C. Y, Wade, H., Tackett, A. J., Strahl, B. D.* & Taverna, S. D.* (2014) A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions. Mol Cell Proteomics. 13:2883-2895.

Wozniak, G. G. & Strahl, B. D. (2014) Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription. Genes & Development. 28:1647-1652.

Jha, D. K. & Strahl, B. D. (2014) H3K36 methylation regulates chromatin remodeling and checkpoint activation after DSB. Nature Commun. 5:3965.

Wozniak, G. G. & Strahl, B. D. (2014) Hitting the 'Mark': Interpreting Lysine Methylation in the Context of Active Transcription. BBA - Gene Regulatory Mechanisms. 10.1016/j.bbagrm.2014.03.002.

Rothbart S. B. & Strahl, B.D. (2014) Interpreting the language of histone and DNA modifications. BBA - Gene Regulatory Mechanisms. 10.1016/j.bbagrm.2014.03.001\

Dronamraju, R. & Strahl, B. D. (2014) A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation. Nucleic Acids Research. 42:870-881.

Rothbart, S. B., Dickson, B. M., Ong, M. S., Krajewski, K., Houliston, S., Kireev, D. B., Arrowsmith, C. H. & Strahl, B. D. (2013) Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes & Development. 27:1288-1298.

Law, J. A., Du, J., Hale, C. J., Feng, S., Krajewski, K., Strahl, B. D., Patel, D. J. & Jacobsen, S. E. (2013) SHH1 recruits RNA Polymerase-IV to RNA-directed DNA methylation targets. Nature. 498:385-389.

Cai, L., Rothbart, S. B., Lu, R., Xu, B., Tripathy, A., Chen, W.-Y., Zheng, D., Patel, D. J., Allis, C. D., Strahl, B. D., Song, J., Wang, G. G. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 49:571-582.

Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyty-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD (2012) Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol. 19:1155-60.

Rothbart SB, Krajewski K, Strahl BD, Fuchs SM (2012) Peptide microarrays to interrogate the histone code. Methods Enzymol. 512:107-135.

Rothbart SB, Lin, S, Britton, L-M, Krajewski K., Keogh M-C., Garcia, Strahl BD (2012) Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Scientific Reports. 2:489.

Fuchs SM, Kizer KO, Braberg H, Krogan N, Strahl BD (2012) RNA polymerase II CTD phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36. J Biol Chem. 287, 3249-3256.

Fuchs SM, Krajewski K, Miller V, Baker RW, Strahl BD (2011) Influence of combinatorial histone modifications on antibody and effector protein recognition. Current Bio. 11, 53-58.

Gardner KE, Zhou L, Parra MA, Chen X, Strahl BD (2011) Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS ONE. 6:e16244.

Fuchs, SM & Strahl BD (2011) Antibody recognition of histone post-translational modifications: emerging issues and future prospects. Epigenomics. 3:247-249.

Ramachandran S, Vogel L, Strahl BD, Dokholyan NV (2011) Thermodynamic stability of protein-protein interaction is a necessary but not sufficient driving force for evolutionary concervation. PLoS Comput Biol. 7:e1001042.

Gardner KE, Allis CD, Strahl BD (2011) OPERating ON chromatin, a colorful language where context matters. J. Mol Bio. 409, 36-46

Fuchs SM, Laribee RN, Strahl BD (2009) Protein modifications in transcription elongation. BBA - Gene Regulatory Mechanisms. 1789:26-36.

Youdell ML, Kizer KO, Kisseleva-Romanova E, Fuchs SM, Duro E, Strahl BD, Mellor J (2008) Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36. Mol. Cell. Biol. 28, 4915-26.

Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, Krogan NJ, Strahl BD, Berger SL (2007) H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol. Cell 27, 275-88.

Ashly G. Rivenbark & Brian D. Strahl (2007) Molecular biology. Unlocking cell fate. Science 318, 403-4

Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD (2007) CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc. Natl. Acad. Sci. USA 104, 5836-41.

Morris SA, Rao B, Garcia BA, Hake SB, Diaz RL, Shabanowitz J, Hunt DF, Allis CD, Lieb JD, Strahl BD (2007) Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem. 282, 7632-40.

Xiao T, Shibata Y, Rao B, Laribee RN, O'Rourke R, Buck MJ, Greenblatt JF, Krogan NJ, Lieb JD, Strahl BD (2007) The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Mol Cell Biol. 27, 721-31.

Biswas D, Dutta-Biswas R, Mitra D, Shibata Y, Strahl BD, Formosa T, Stillman DJ (2006) Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. EMBO J. 25, 4479-89.

Laribee RN, Fuchs SM, Strahl BD (2007) H2B ubiquitylation in transcriptional control: a FACT-finding mission. Genes Dev. 21, 737-43.

Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ (2005) Cotranscriptional Set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123, 593-605.

Rao B, Shibata Y, Strahl BD, Lieb JD (2005) Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide. Mol Cell Biol. 25, 9447-59.

Laribee RN, Krogan NJ, Xiao T, Shibata Y, Hughes TR, Greenblatt JF, Strahl BD (2005) BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr Biol. 15, 1487-93.

Morris SA, Shibata Y, Noma K, Tsukamoto Y, Warren E, Temple B, Grewal SI, Strahl BD (2005) Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell. 4, 1446-54.

Kizer KO, Phatnani HP, Shibata Y, Hall H, Greenleaf AL, Strahl BD. (2005) A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol. 25, 3305-16.

Xiao T, Kao CF, Krogan NJ, Sun ZW, Greenblatt JF, Osley MA, Brian D. Strahl (2005) Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol. 25, 637-51.

Lee CK, Shibata Y, Rao B, Strahl, BD & Lieb JD (2004) Evidence for nucleosome depletion at active regulatory regions genome-wide. Nat Genet. 36, 900-905.

Xiao T, Hall H, Kizer KO, Shibata Y, Hall MC, Borchers CH, Brian D. Strahl (2003) Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev. 17, 654-63.

Briggs SD, Xiao T, Sun ZW, Caldwell JA, Shabanowitz J, Hunt DF, Allis CD, Brian D Strahl (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418, 498.

Brian D. Strahl & C. David Allis (2000) The language of covalent histone modifications. Nature 403, 41-5

For complete information on papers from Brian Strahl's lab, follow this link to PubMed or Brian Strahl's google scholar page